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Ever since a terrible childhood tragedy, Minoru Utsugi has wished for one thing: solitude. Years later, a bizarre encounter leaves a mysterious artifact in Minoru's body that grants his wish--but that's far from the end of his troubles. Others have been visited and given powers like Minoru's, but their twisted desires are not so benign. When a murderous force threatens the people Minoru holds dear, will his newfound abilities be enough to stand in its way? And can there be a future for someone who craves eternal solitude above all else? The story of the Isolator begins here!

An alien parasite living inside of Minoru Utsugi gives him the power of Isolation--an unbreakable shield that surrounds his body. With this power, he's managed to defeat an evil Ruby Eye. Having done so, he's invited by the Accelerator--a girl named Yumiko--to join a mysterious organization whose goal is to defend humanity from the threat of the Ruby Eyes. Minoru agrees to join, with one condition: Once he has fulfilled his duty, the syndicate will erase all memory of his existence from the world--for Minoru seeks a world without any knowledge of him, a world of total and perfect isolation.

Having successfully helped destroy two of the evil Ruby Eyes, Minoru, the Isolator, is recruited by the Syndicate, a secret organization dedicated to their eradication. He teams up with Suu Komura, the Refractor, a young girl said to be the Syndicate's most powerful member, to attack a secret stronghold of the Ruby Eyes. Their target is the most fearsome opponent they've ever faced: the Liquidizer, but their enemy is not what they expected...

After infiltrating the Ruby Eye hideout, Minoru Utsugi falls into a deadly trap but narrowly escapes thanks to the Refractor's desperate sacrifice. Though her gambit saved them both from the Liquidizer's scheme, Suu paid for it dearly, leaving her in critical condition. After this tragedy, Minoru must find his place in this new, dangerous world again but his enemies won't wait now that the Stinger has arrived, ready to crush the Syndicate!